July 27, 2010 
I don’t think any of us who spend a lot of time in the adherence area are surprised by this, but it’s always good to have a nice, published study to reinforce the point.
CVS Caremark published a study done last year using interactive outbound call technology to improve their adherence program. (Chang et al., Improving Persistency for Maintenance Medication Therapy Through an Interactive Voice Response Program, Journal of Managed Care Pharmacy, 2010. 16 (2): page 156.) It showed that being proactive (i.e., calling before the patient ran out of pills) was better than doing nothing (control group) and better than calling reactively (i.e., the patient has run out of pills). But, if you do both, you significantly improve the likelihood of them getting a refill and staying adherent.
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